Question

0.5 micro mol of a drug is dissolved in a mixture of octonol and water. After equilibration 0.05 micro mol is dissolved in octonol and rest in water. What is its LogP.​

Answer 1

Dear Student,

◆ Answer -

LogP = -0.9542

● Explaination -

LogP is the partition coefficient of a molecule between an aqueous and lipophilic phases.

Here, log of partition coefficient is calculated as -

LogP = log (conc in octanol / conc in water)

LogP = log[0.05/(0.5-0.05)]

LogP = log(0.05/0.45)

LogP = -0.9542

Therefore, logP value of drug is -0.9542.

Thanks dear...