Question

0. Conversion of glucose to glucose–6–phoshphate, the first irreversible reaction of glycolysis, is cata- lyzed by​

Answer 1

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Explanation:

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Answer 2

Conversion of glucose to glucose–6–phoshphate, the first irreversible reaction of glycolysis, is catalyzed by​ Hexokinase.

• Glycolysis is a sequence of reactions taking place in the cytosol of a cell in absence of oxygen. It converts one molecule of glucose, a 6C compound into 2 molecules of pyruvate a 3C compound.

• In the first step of the glycolytic pathway, glucose is phosphorylated to glucose 6-phosphate at the expense of one ATP.

        Glucose + ATP ⇒ Glucose 6-phosphate + ADP + H+

• Phosphorylation of glucose at C-6 by inorganic phosphate has a ΔG°’ of 13.8 kJ/mo. It is an irreversible reaction.
• Phosphorylation causes an increase in the energy content of the molecule, hence it starts to destabilize and facilitate its further metabolism.