0. Where HSP 90 proteins are located in cell?
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The protein-binding region of Hsp90 is located toward the C-terminus of the amino sequence.
Each domain within the HSP90 structure performs a specific function. The NTD binds to the ATP, hence, called the nucleotide-binding site. The CTD is responsible for protein dimerization and contains special motifs MEEVD or KDEL depending on the HSP90 isoform and its cellular location either in the cytoplasm or the ER
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