1. Cells that need NADPH as much as they need Ribose 5 phosphate
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1. Many cell types need NADPH for reductive biosynthesis processes much more than they need ribose 5-phosphate.
2. The cells need more ribose 5-phosphate for the synthesis of DNA they can generate it from glucose 6-phosphate via reactions of glycolysis and the pentose phosphate pathway.
3. In these cases, ribose 5-phosphate is recycled back to glucose 6-phosphate via glycolytic intermediates.
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