1. In sickle-cell anaemia , the substitution of amino acid in the globin protein results due to the single base substitution at the sixth codon of the beta globin gene from
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As previously mentioned, in sickle-cell anemia, the gene for beta globin is mutated. The resulting protein still consists of 147 amino acids, but because of the single-base mutation, the sixth amino acid in the chain is valine, rather than glutamic acid. This substitution is depicted in Table 1.
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