1 What makes rough endoplasmic reticulum rough?
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It is called 'rough' endoplasmic reticulum because it is studded on its outer surface (the surface in contact with the cytosol) with ribosomes. ... Ribosomes on the rough endoplasmic reticulum are called 'membrane bound' and are responsible for the assembly of many proteins. This process is called translation.
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Rough ER is called rough because it has ribosomes attached to its surface. The double membranes of smooth and rough ER form sacs called cisternae. Protein molecules are synthesized and collected in the cisternal space/lumen. When enough proteins have been synthesized, they collect and are pinched off in vesicles.
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