Question

10. Of the following antihistaminic drugs ----------is having least CNS effects:
a. Loratadine
b. Azatadine
C. Cyproheptadine
d. Astemizole​

Answer 1

Answer:

Azatadine

Explanation:

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Answer 2

Required Answer :-

C. Cyproheptadine

Explanation :-

Somnolence. Although fexofenadine is devoid of CNS effects, many other second-generation H1-antihistamines still penetrate the brain to a small extent where they have the potential to cause some degree of drowsiness or somnolence, particularly when used in higher doses.

• In vivo, five antihistamines showed anticholinergic activity: cyproheptadine>promethazine>desloratadine>loratadine>diphenhydramine. The remaining antihistamines had no significant effect at i.v. infusion doses up to 50 imol/kg. Cetirizine and fexofenadine did not antagonize cholinergic responses in either model.

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