Question

10. The sigmoidal, cooperative binding curve commonly observed for hemoglobin is a result of:
a) competition between CO2 and O2 for heme binding.
B) competition between heme and distal His for O2 binding
c) competition between BPG and CO2 for binding at the central cavity site
d) T to R transition

11. Hemoglobin has a tendency to release its oxygen to the tissues because:
a) in this region pH is high and O2 concentrations are low
b) in this region both pH and O2 concentrations are low
c) in this region both pH and O2 concentrations are high
d) there is much BPG in this region

12. Which statement about fetal hemoglobin is not true?
A) fetal hemoglobin has gamma chains instead of beta chains
b) fetal hemoglobin binds BPG less strongly than maternal hemoglobin
c) fetal hemoglobin binds oxygen less strongly than maternal hemoglobin
d) fetal hemoglobin binds oxygen more strongly than maternal hemoglobin

13. Which process is most responsible for the sickling of cells seen in sickle cell disease?
A) aggregation of the oxygenated R form of hemoglobin-S to form insoluble fibers
b) aggregation of the deoxygenated T form of hemoglobin-S to form insoluble fibers
c) Hemoglobin-S does not contain heme
d) Hemoglobin-S contains a mutant form of heme which will not bind oxygen

14. A person with a genetic defect which results in the synthesis of an insufficient amount of the alpha chain of hemoglobin is said to have which disease?
A) alpha thalassemia
b) beta thalassemia
c) pernicious anemia
d) Crohn’s disease
15. A person with sickle-cell trait is very unlikely to catch which disease?
A) malaria
b) colon cancer
c) avian flu
d) whooping cough 15.

Answer 1

hbccxxhhgffxcbhhjgvvb