Question

12. If a female who is carrier of haemophilia allele marries a normal male and they have a son, then
a. What is the probability that the son will have haemophilia?
b. What kind of inheritance is evident from the above example?
c. Which chromosome bears the haemophilia allele?​

Answer 1

Answer:

If she gets the X chromosome with the hemophilia gene, she will have hemophilia. A man who has hemophilia and a woman who is a carrier have: a 25% (one in four) chance of having a son with hemophilia. a 25% chance of having a son with normal blood clotting.

a) There is a 50% chance that each son will have hemophilia. There is a 50% chance that each daughter will be a carrier of the hemophilia gene..

b) Many health conditions are caused by the combined effects of multiple genes (described as polygenic) or by interactions between genes and the environment. Such disorders usually do not follow the patterns of inheritance listed above.

c) Some well known genetic disorders mapping to X-chromosome are Duchenne Muscular Distrophy (DMD), haemophilia, Becker Muscular Distrophy (BMD), retinitis pigmentosum type 2 & 3 and colour blindness.

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