2) Ebright's research in his early years set the foundation for his success. Elucidate.
Answers
Answer:
Ebright's research results include the experimental demonstration that amino-acid-base contacts mediate DNA sequence recognition in protein–DNA interaction,the determination of the three-dimensional structural organization of the transcription initiation complex;the demonstration that transcription start-site selection and initial transcription involve a "DNA scrunching" mechanism; the demonstration that transcription activation can proceed by a "recruitment" mechanism;the demonstration that bacterial transcription-translation coupling involves direct physical bridging of RNA polymerase and a ribosome by NusA and NusG; and the identification of novel antibacterial drug targets .
In 1994, Ebright was awarded the American Society of Biochemistry and Molecular Biology Schering-Plough Award for his research on transcription activation.
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Answer:
Ebright's research results include the experimental demonstration that amino-acid-base contacts mediate DNA sequence recognition in protein-DNA interaction,the determination of the three-dimensional structural organization of the transcription initiation complex;the demonstration that transcription start-site selection and initial transcription involve a "DNA scrunching" mechanism; the demonstration that transcription activation can proceed by a "recruitment" mechanism;the demonstration that bacterial transcription-translation coupling involves direct physical bridging of RNA polymerase and a ribosome by NusA and NusG; and the identification of novel antibacterial drug targets.
In 1994, Ebright was awarded the American Society of Biochemistry and Molecular Biology Schering-Plough Award for his research on transcription activation.