29.
Which of the following statements is not
correct?
The proinsulin has an extra peptide called
C-peptide.
The functional insulin has A and B chains
linked together by hydrogen bonds.
(3)
Genetically engineered insulin is produced
in E-Coli.
(4)
In man insulin is synthesised as a
proinsulin.
Answers
Answered by
2
The incorrect statement is the functional insulin has A and B chains linked together by hydrogen bonds.
Answer:
Option 2 is incorrect.
KEY:
The functional insulin has A and B chains linked together by DISULPHIDE bonds.
Explanation:
- The hormone insulin in man is usually synthesized in inactive form called pro insulin.
- This insulin pro hormone is functionally inactive.
- The pro insulin has three polypeptide chains namely A, B and C
- For the insulin to become active, the C peptide should be removed from pro insulin.
- So the mature and active insulin contains only A and B polypeptides linked together by disulphide bonds
- The deficiency of insulin hormone causes diabetes mellitus.
- Such person who are unable to produce sufficient insulin hormone can be treated by introducing insulin artificially in their body.
- This can be achieved by genetic engineering process.
- An American company called ELI LILLY succeeded in producing genetically engineered insulin in E.Coli
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