42. Sulphamethazine is prepared by the condensation of
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Synthesis Sulfamethazine is prepared by reacting acetylsulfanilyl chloride with 2-amino-4,6- dimethylpyrimidine suspended in dry pyridine or in acetone and pyridine, followed by alkaline hydrolysis of the 2-(N4-acetylsulfanilamido)-4,6- dimethylpyrimidine; the resulting salt being neutralized with S02.
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