Question

6. Dr. Lorraine also explains to Mr. Volpe that H. pylori impairs the normal buffering effect in his duodenum. What does she mean by the "buffering effect?" How does the duodenum accomplish this, and in what way does this protect the duodenum?

Answer 1

Normally, when the acidic chyme is moved into the duodenum it signals the pancreas to secrete bicarbonate-rich juice into the duodenum and duodenal submucosal glands, and to secrete a mucus that is also rich in bicarbonate. The amount of the bicarbonate (a base) that is produced is approximately equivalent to the amount of HCl produced in the stomach. The protection this secretion offers is twofold: neutralization of the acidic chyme (raising the pH), and coating the duodenal wall in viscous, alkaline mucus. H. pylori diminishes the release of bicarbonate-rich mucus, leaving the intestinal wall vulnerable to erosion by the acidic chyme.

Explanation:

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