Question

A cell-autonomous tumour suppressor role of raf1 in hepatocarcinogenesis

Answer 1

Explanation:

The phenotypes depend on increased YAP1 expression and STAT3 activation, observed in cultured RAF1-deficient cells, in HCC xenografts, and in autochthonous liver tumours. Thus RAF1, although essential for the development of skin and lung tumours, is a negative regulator of hepatocarcinogenesis