Question

A drug has half-life of 30 minutes in its native form. PEG is conjugated to the drug to improve its pharmacokinetics and the modified drug is injected intravenously with a initial plasma concentration of 1 mg/ml. After 12 hours, the concentration of drug in serum is 0.5 mg/ml. Calculate the change in the half-life of the drug after modification

Answer 1

Change in half life should be 11 hr 30 minutes.

Answer 2

Answer:

A drug has half-life of 30 minutes in its native form. PEG is conjugated to the drug to improve its pharmacokinetics and the modified drug is injected intravenously with a initial plasma concentration of 1 mg/ml. After 12 hours, the concentration of drug in serum is 0.5 mg/ml. the change in the half-life of the drug after modification is 11hr 30 minutes