(a) Give all the possible genotypes of the numbers 4, 5, 6 in the pedigree chart.
(b) A blood test show that individual 14 is carrier of Hemophilia and married individual 15. what is the probability of their 1st child will be Hemophilia male?
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Let the dominant allele be 'A' and let the recessive allele be 'a'.
(a) Member 4 could be Aa (carrier) or aa (unaffected).
Member 5 is aa (affected).
Member 6 could be Aa (carrier) or aa (unaffected).
(b) Member 14 is a carrier female which means the genotype is Aa. Member 15 is an unaffected male (AA). So, the probability that the first child is a haemophilic male is 1/4.
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