A gold surface was grafted with a polymer. The ends of this polymer are tagged with 4 pendant groups: namely group A, B, C and D. The pendant groups are weak acids. The modified isoelectric point of the entire polymer were calculated to be as follows:
Group pI
A 4.5
B 5.5
C 7.4
D 9
These particles are loaded with a positively charged drug on the surface using electrostatic interaction in PBS (pH=7.4). Which of the following will have minimum loading?
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Answer:
B ...................
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