Question

A is the brother of C; D is C's mother. D is B's sister and E is B's sister. How is C related to E?

Answer 1

since D and E are sisters therefore E might be C's aunt.

Answer 2

A is the brother of C

Thus, A and C are siblings.
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D is C's mother

So D is mother of both A and C
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D is B's sister and E is B's sister.

So B, D and E are sisters.

B and E are aunts of A and C.
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$\boxed{ \red{ \textbf{C is nephew of E.}}}$