Question

A new approach to the synthesis of tazobactam using an organosilver compound synthesis, (3), 442-446; 2005

Answer 1

Tazobactam (9) was synthesized in 8 steps from the readily accessible 6 -APA . by the first use of silver triazole as reactant ,the formation of the isomer 7 was avoided and a total yield of 50% which was 2 to 3 times higher than that of reported procedures for 9, was obtained.