Question

A normal strand of DNA is shown below, followed by the same strand of DNA after mutations have occurred. Identify the mutation and explain the effect it would have on protein synthesis. A) This mutation is a point mutation resulting from a base substitution. This would results in the different reading of the one codon affected by the mutation, causing the substitution of a different amino acid in an otherwise unaltered protein. B) This mutation is a deletion mutation resulting in a frameshift. This would result in a different reading of the codons following the mutation, causing a different translation from the original strand. The protein being created could be abnormally short, abnormally long, and will most likely not be functional. C) This mutation is an addition mutation resulting in a frameshift. This would result in a different reading of the codons following the mutation, causing a different translation from the original strand. The protein being created could be abnormally short, abnormally long, and will most likely not be functional. D) This mutation is a substitution mutation resulting in a frameshift. This would result in a different reading of the codons following the mutation, causing a different translation from the original strand. The protein being created could be abnormally short, abnormally long, and will most likely not be functional.

Answer 1

Answer:

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Although the haploid human genome consists of 3 billion nucleotides, changes in even a single base pair can result in dramatic physiological malfunctions. For example, sickle-cell anemia is a disease caused by the smallest of genetic changes. Here, the alteration of a single nucleotide in the gene for the beta chain of the hemoglobin protein (the oxygen-carrying protein that makes blood red) is all it takes to turn a normal hemoglobin gene into a sickle-cell hemoglobin gene. This single nucleotide change alters only one amino acid in the protein chain, but the results are devastating.

Beta hemoglobin (beta globin) is a single chain of 147 amino acids. As previously mentioned, in sickle-cell anemia, the gene for beta globin is mutated. The resulting protein still consists of 147 amino acids, but because of the single-base mutation, the sixth amino acid in the chain is valine, rather than glutamic acid.

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