Question

A researcher is studying the infection of cells by the SARS-CoV-2 virus. In the lab, virus obtained from patient isolates is added to cultured cells, and the accompanying electron micrograph shows such a cultured cell being infected with the virus. Several of the virus particles are indicated by black arrows (many more are unlabeled), and the position of the plasma membrane is indicated by the yellow dotted line. These virus particles bind to their receptor on the plasma membrane, which has been identified as the ACE2 (angiotensin-converting enzyme 2) protein. ACE2 is an integral membrane protein with a glycosylated extracellular amino-terminal domain and an intracellular carboxy-terminal domain. The researcher has a theory that the fluidity of ACE2 on the plasma membrane might affect its conformation and perhaps the rate of viral infection.

Which of the following would most decrease the membrane fluidity of an unoccupied ACE2 receptor on cultured cells incubated at 37°C?

A) Binding of a SARs COv 2 virus particle to the receptor ( ie. becoming redeptor).

b) Addition of 1.0 M Nacl to the extracellular fluid.

c) Enzymatic removal of the sugars from its extracellular domain.

D) Binding of its carboxylic terminal domain to the cytoskeleton.​

Answer 1

Answer:

SARS-CoV-2 stability similar to original SARS virus. ... from the surface of cells (blue/pink) cultured in the lab. ... the National Institute of Allergy and Infectious Diseases'