Question

(a) Sickle celled anaemia in humans is a result of point mutation. Explain.
(b) Write the genotypes of both the parents who have produced a sickle celled anaemic offspring.

Answer 1

Answer:

a. Sickle cell anemia is categorized as a point mutation because it results from the change in single base pair for beta globin chain. The change results in formation of valine instead of glutamate.

b. Genotype for the parents with and offspring with sickle cell anaemia will be HbA/HbS and HbA/HbA or it may be HbS/HbS and HbA/HbS.

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