Question

A single germline mutation in the adenomatous polyposis coli (a protein that in humans is encoded by the apc gene) tumor suppressor gene is responsible for the dominantly inherited syndrome familial adenomatous polyposis. Clinical expression of the disease is seen when the inherited mutation of one apc allele is followed by a second hit mutation or deletion of the second allele.

Answer 1

Familial adenomatous polyposis can have different inheritance patterns and different genetic causes. When this condition results from mutations in the APC gene, it is inherited in an autosomal dominant pattern, which means one copy of the altered gene is sufficient to cause the disorder