A specific chemical difference between the globins of normal human and sickle-cell anaemia haemo- globin.
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a chemical different between the globis normal human and sickle cell anaemia is a normal human globin is a hbA and hbS the disease is controlled by single pair of allele....HbA and hbS...
out of the three possible genotypes only homozygous individuals for hbS ( hbS hbS) show the disease phenotype ... heterozygous ( HbA Hbs ) ...the defect is caused by the substantion of glutamic acid by valine. .
normal human RBC is disc type and Carrier of sickle cell anaemia is elogated biconcave...
out of the three possible genotypes only homozygous individuals for hbS ( hbS hbS) show the disease phenotype ... heterozygous ( HbA Hbs ) ...the defect is caused by the substantion of glutamic acid by valine. .
normal human RBC is disc type and Carrier of sickle cell anaemia is elogated biconcave...
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THE CHEMICAL DIFFERENCE BETWEEN NORMAL HUMAN AND SICKLE CELL ANAEMIA HAEMOGLOBINS. ... I can now report that these carboxyl groups belong to glutamic acid and that they are replaced by two valine residues in haemoglobin S. This appears to be the only chemical difference between the two proteins.
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