Question

A three-year-old boy was being treated for scid using a modified retrovirus, but the boy developed a leukemia-like condition. What appeared to have caused this

Answer 1

Answer:

Severe combined immunodeficiency (SCID), sometimes called 'Boy in ... Paris developed leukemia between 3 and 6 years after the treatment.

Answer 2

The reason for this is as follows:

• The main reason for happening this is that this modified retrovirus has been inserted near the proto-oncogene promoter of leukemia.

• The leukemia-like condition of clonal lymphocyte proliferation was shown to be related to retrovirus vector integration near the LMO2 (LIM domain only 2) proto-oncogene promoter leading to activation and expression of LMO2. The LMO2 protein plays a major role in hematopoietic development.

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