absorption of glucose
Answers
Explanation:
Glucose absorption is associated with hyperinsulinemia and may lead to weight gain. Studies suggest that the increase in weight is primarily driven by an increase in fat mass and is more likely to occur in individuals with polymorphism of the uncoupling protein-2 gene which can alter the metabolic rate. Alterations in body composition may be less likely for patients treated with icodextrin. Patients using icodextrin for a single long-dwell are less likely to have significant increases in total fat mass, visceral fat area, total weight gain, and waist/hip ratio than those treated exclusively with glucose-based dialysate. This is probably due to the lower absolute rate of peritoneal absorption of icodextrin. Notwithstanding the potential importance of glucose absorption, in a study of a large cohort of patients new to dialysis, significant weight gain was more likely to occur in patients treated with maintenance hemodialysis rather than those with peritoneal dialysis. This suggests that while glucose absorption is a potentially important cause of weight gain in PD patients, amelioration of uremic anorexia may be a more important cause of significant weight gain in patients starting dialysis therapy.