According to dsm 4 tr refers to a pttren of compulsive subtsnce use in which tolerance and withdrawal may occur
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For example, severe substance use disorders, commonly called addictions, were once .... and structural changes in the brain that result from alcohol and drug use. .... This is called tolerance and may lead to use of the substance in greater ... Compulsive substance seeking is a key characteristic of addiction, as is the loss of ...
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