Question

Activation of pyruvate dehydrogenase catalytic activity by which factor

Answer 1

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♒The pyruvate dehydrogenase complexlinks glycolysis to the TCA cycle (also known as the Krebs cycle or the citric acid cycle).

✔✔It is a large multi-enzymecomplex composed of three enzymes involving five cofactors. The pyruvate dehydrogenase complex oxidizespyruvate to generate acetyl-coA.

♨Structure

EnzymesAbbrev.Cofactorspyruvate dehydrogenase (EC 1.2.4.1)E1TPP (thiamine pyrophosphate)dihydrolipoyltransacetylase (EC 2.3.1.12)E2lipoate coenzyme Adihydrolipoyldehydrogenase (EC 1.8.1.4)E3FAD NAD+

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Answer 2

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Regulation of the pyruvate dehydrogenase complex. Only the first enzyme component, pyruvate dehydrogenase, is regulated. Both insulin and pyruvate stimulate production of the unphosphorylated, active form. The products of the reaction, NADH and acetyl-CoA, promote a lower percentage of the PDH in the active form.

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