adaptive features & corona activity
Answers
Answer:
So far, data suggests that children under the age of 18 years represent about 8.5% of reported cases, with relatively few deaths compared to other age groups and usually mild disease. However, cases of critical illness have been reported. As with adults, pre-existing medical conditions have been suggested as a risk factor for severe disease and intensive care admission in children.
Further studies are underway to assess the risk of infection in children and to better understand transmission in this age group.
Explanation:
Answer:
Key amino acids in the SARS coronavirus spike protein and the receptor protein that determine the host range of the virus.
(A) There is a large binding interface between a loop structure in the spike protein of the human SARS coronavirus of 2002-2003 and its human receptor ACE2.
(B) Two amino acid substitutions in the spike protein of a civet SARS virus reduce receptor activity of human ACE2 by adding a charge to the binding surface (N479K) and deleting a key methyl group (T487S) that fits into a hydrophobic pocket in the receptor.
(C) In the spike protein from coronavirus of a mild SARS case from 2003-2004, the key methyl group is also missing and a proline residue (L472P) reduces the binding surface.
(D) Rat ACE2 contains a large glycan at M82N and lacks the hydrophobic pocket (K353H).
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