advantages and disadvantages of Gene Therapy
Answers
1. Gene silencing is a concept that in itself is self-efficient for management of many diseases.
2, Gene therapy has the potential to eliminate and prevent hereditary diseases, such as cystic fibrosis, and is a possible cure for heart disease, AIDS and cancer.
3. Gives an advantage to a person born with genetic disorder to live life in a normal way by replacing non-functional gene with a functional one.
Disadvantages of Gene Therapy:
1. Irregular immune responses.
2. Viral vectors may introduce toxicity, as well as immune and inflammatory responses.
3. Multi-gene disorders such as heart disease, high blood pressure, Alzheimer’s disease, arthritis, and diabetes cannot be treated through this therapy as conditions or disorders that arise only from mutations in a single gene are the best candidates for gene therapy.
4. Religious concerns.
5. Chances of inducing iatrogenic (physician induced) tumours in human beings.
6. Short-lived nature of gene therapy.
Answer:
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Explanation:
It is not always successful yet disease can be eradicated for a person and their future offspring, so it is a remedy not just one generation but also in succeeding generations. . For example, a baby just born can undergo gene therapy in the womb to remove the breast cancer gene, as both parents had strong family histories of the cancer. As a result, unless the child is exposed to lots of carcinogens, child has no chance of developing the cancer. This is one of many cases where a genetic illness has been virtually eradicated.
Gene therapy has the potential to eliminate and prevent hereditary diseases such as cystic fibrosis and is a possible cure for heart disease, AIDS and cancer. Genetic disease can be cured by replacing non-functional gene with a functional one. This may give someone a chance of normal life.
Gene therapy can 'silence' a gene. In the case of someone with HIV, which had not yet developed into AIDS, scientists could save them the pain and suffering of the disease by using gene therapy to 'silence' the disease before its onset.
• Short-lived nature of gene therapy which makes the patients to undergo multiple rounds of gene therapy.
• Immune response is of stimulated that reduces gene therapy effectiveness which is always a potential risk.
• Problems with viral vectors - Viruses, which is used as vehicles in most gene therapy present a variety of potential problems to the patient --toxicity, immune and inflammatory responses, and gene control and targeting issues. In addition, there is always the fear that the viral vector, once inside the patient, may recover its ability to cause disease.
• Multigene disorders, such as heart disease, high blood pressure, Alzheimer's disease, arthritis, and diabetes, are caused by the combined effects of variations in many genes. Multigame disorders such as these would be especially difficult to treat effectively using gene therapy.
• Also, there are a few side effects. These include nausea and temporary drowsiness.
• For the diagnosis of disease in a fetus or embryo before it is born prenatal testing is performed. If an unborn carries any defective gene then their parent's definitely want to abort this child this may increase number of abortions. This is major disadvantage of gene therapy. This creates many ethical problems.