Advantages and disadvantages of using viral vectors for gene therapy
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1. Retrovirus
Advantages80cb750a6a4b725a21297caefb278835
Enters cells efficiently
Viral genes absent
Integrates stably
Disadvantages
Hard to produce
Limited Insert size
Random Mutagenesis
2. Adenovirus
adenovirus-2-4-638
Advantages
Enters cells efficiently
Produces high expression of therapeutic gene
Does not integrate into host chromosome
Disadvantages
Viral genes must be in vector
Induces immune response
3. Adeno-associated virus
Microsoft PowerPoint - YST_MAM_Figure1.pptx
Advantages
Integrates into chromosome at specific site
Does not produce immune response
Disadvantages
Small insert size allowed
Hard to produce
4. Herpesvirus
herpes-virus
Advantages
Produced at high levels
Targets nondividing nerve cells
Disadvantages
Hard to produce
Viral gene required
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