Question

Alcol excess intake and excess water retentity in the bladder -what to do?

Answer 1

Vommit.............

Answer 2

Answer:

Explanation:

THE ability of chlorpropamide to reduce urinary

volume in patients with neurogenic diabetes insipidus

has been recently described by Arduino, Ferraz &

Rodriguez (1966), Meinders, Touber & De Vries

(1967), Reforzo-Membrives et al. (1968), Hocken &

Longson (1968), and Andreani, Cinotti & Stirati

(1969).

This therapy is potentially of great importance in

the treatment of neurogenic diabetes insipidus;

therapy with chlorpropamide, however, is not always

without complications both in the short or longterm management of these patients. Initially there were no reports that patients with

diabetes insipidus undergoing therapy with chlorpropamide were prone to hypoglycaemic episodes

(Meinders, Touber & De Vries, 1967; ReforzoMembrives et al., 1968), but with increasing use of

this type of therapy it soon became apparent that

hypoglycaemia was the most frequent and important

complication.

We have observed symptomatic hypoglycaemia

in the early phases of treatment, but with continued

treatment it becomes less frequent (Cinotti et al.,

1969).

In this paper we emphasize that these patients,

when treated with chlorpropamide, may be also

subject to water retention and may present the

clinical symptoms of water intoxication.

Observations on a patient with idiopathic neurogenic diabetes insipidus (INDI) who developed

water retention and mild symptomatic hyponatraemia during long-term treatment with chlorpropamide are reported. This case may also raise some

intriguing questions concerning the mechanism of

action of chlorpropamide and the physiopathology

of diabetes insipidus.