Question

alfa ketogutaric acid + NH4+ + NADPH - glatamate​

Answer 1

The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mitochondrial glutamate dehydrogenase 1 (GLUD1) catalyzes the reversible reaction of glutamate and NAD(P)+ to form 2-oxoglutarate, NAD(P)H + H+, and ammonia . Mature GLUD1 protein lacks the 53 aminoterminal residues of the nascent protein , which function as a mitochondrial import signal. The active form of the enzyme is a hexamer, allosterically activated by ADP and inhibited by GTP