Question

An aqueous solution contains 0.432 M acetic acid. How many mL of 0.360 M potassium hydroxide would have to be added to 150 mL of this solution in order to prepare a buffer with a pH of 4.710​

Answer 1

Answer:

Explanation:

Which ONE of the following is the best description of a protogenic solvent?

a) A protogenic solvent accepts electron lone pairs

b) A protogenic solvent neither accepts or donates protons

c) A protogenic solvent donates protons

d) A protogenicWe use cookies to enhance your experience on our website. By clicking 'continue' or by continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time.

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Denton & Rostron: Pharmaceutics

Chapter 6: Multiple choice questions

Instructions

Answer the following questions and then press 'Submit' to get your score.

Question 1

Which ONE of the following is the best description of a protogenic solvent?

a) A protogenic solvent accepts electron lone pairs

b) A protogenic solvent neither accepts or donates protons

c) A protogenic solvent donates protons

d) A protogenic solvent donates or accepts electron lone pairs

e) A protogenic solvent accepts protons

Question 2

For an aqueous solution of hydrochloric acid (HCl) the pH was found to be 4.18 units. What is the concentration of HCl in this solution?

a) 2.2 x10-3 M

b) 1.4 x 10-3 M

c) 3.2 x 10-4 M

d) 4.8 x 10-4 M

e) 6.6 x 10-5 M

Question 3

What is the pH of a 0.015 M solution of potassium hydroxide (KOH)?

a) 1.8

b) 12.2

c) 5.6

d) 8.8

e) 13.1

Question 4

A solution of the weakly basic drug erythromycin (pKb = 5.2) is buffered to pH 7.4.

What percentage of the drug will be ionised at this pH?

a) 25%

b) 72%

c) 75%

d) 96%

e) 99%

Question 5

A solution of diclofenac (pKa = 4.15) is buffered to pH 5.5. How much diclofenac will be ionised at this pH?

a) 100%

b) 96%

c) 50%

d) 22%

e) 1%

Question 6

A buffer solution contains 0.36 M sodium acetate (CH3COONa) and 0.45 M acetic acid (CH3COOH), pKa = 4.8. What is the pH of this buffer solution?

a) 4.7

b) 5.2

c) 3.8

d) 6.1

e) 6.9

Question 7

250 mL of a buffer contains 0.05 mol acetic acid (CH3COOH) and 0.03 mol sodium acetate (CH3COONa). What is the maximum buffer capacity of this buffer?

a) 0.46 mol L-1 pH unit-1

b) 0.18 mol L-1 pH unit-1

c) 0.22 mol L-1 pH unit-1

d) 1.84 mol L-1 pH unit-1

e) 3.24 mol L-1 pH unit-1

Question 8

What is the isoelectric point for phenylalanine given the pKa for the COOH group is 1.83 and the NH3+ group is 9.13?

a) 2.43

b) 4.83

c) 5.48

d) 9.13

e) 10.96

Question 9

Which one of the following statements is true?

a) A strong electrolyte solution is a solution that always contains a high concentration of an acid or base.

b) The strength of an acid can be influenced by the solvent into which it is placed

c) In aqueous solution a strong acid will dissociate to form a strong conjugate base and together these form a conjugate pair.

d) pH 7 is considered to be neutral pH at all temperatures

e) A buffer solution has a fixed pH value that does change at all upon the addition of acid or base.

Question 10

Which one of the following statements concerning active pharmaceutical ingredients (APIs) is false?

a) The degree of ionisation of an API is dependent upon its pKa or pKb.

b) The degree of ionisation of an API is dependent upon the pH of the surrounding solution.

c) The extent to which an API may be absorbed is influenced by the extent of its ionisation

d) APIs pass through biological membranes more readily when they are ionised

e) Temperature can affect the degree of ionisation of APIs

 

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Denton & Rostron: Pharmaceutics

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