Antacids physiological role of histamine and serotonin
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Histamine and serotonin. The most important vasoactive mediators that are stored in mast cell and basophil granules are histamine in man, as well as serotonin or 5-hydroxytryptamine in rodents. They both are also present in human platelets. ... A number of different cells of the body have receptors for histamine.
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The effects of 8-week treatment with oral histamine H2-antagonists (ranitidine or cimetidine) or an antacid on plasma levels of histamine and serotonin were studied in duodenal ulcer patients. ... Antacid treatment similarly increased histamine levels without significantly affecting blood serotonin
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