Antibody dependent cell cytotoxicoty biology discussion
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Role of Antibodies:
Humoral immunity is antibody-mediated. It protects body from extracellular pathogenic agents by combining with them to form antigen-antibody complex, leading eventually to their elimination. The antibodies play at least in three different ways in this process of elimination of an antigenic agent.
Firstly, the antibody can bind to the surface epitopes of the antigen making it more susceptible to phagocytosis. This is known as opsonization.
Secondly, the antibody molecule can bind to the antigen forming an antigen-antibody complex which then combines with the complement in a step-wise manner to initiate and facilitate phagocytosis of the antigen.
Thirdly, the antibody can bind to toxin molecules elaborated by microbes making them non-toxic. In a similar manner, antibodies can inactivate free virus particles by combining with the epitopes on viral particles to make them incapable of attachment to host cell membranes.
Humoral immunity is antibody-mediated. It protects body from extracellular pathogenic agents by combining with them to form antigen-antibody complex, leading eventually to their elimination. The antibodies play at least in three different ways in this process of elimination of an antigenic agent.
Firstly, the antibody can bind to the surface epitopes of the antigen making it more susceptible to phagocytosis. This is known as opsonization.
Secondly, the antibody molecule can bind to the antigen forming an antigen-antibody complex which then combines with the complement in a step-wise manner to initiate and facilitate phagocytosis of the antigen.
Thirdly, the antibody can bind to toxin molecules elaborated by microbes making them non-toxic. In a similar manner, antibodies can inactivate free virus particles by combining with the epitopes on viral particles to make them incapable of attachment to host cell membranes.
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