Question

ANTONY: Now let it work, mischeif, thou art afoot,
take thou what course thou wilt

EXPLAIN THE LINE

Answer 1

In this line Antony tells that he is able to create mischief and tells that mischief take your direction as he is able to sway away the tide against the conspirators by inciting the Roman mob.

Answer 2

Heyya

Explanation is

Now that trouble has begun, let run its natural course and Antony leaves

I hope it Will help u