Question

anyone knows why sn2 reaction prefer polar aprotic solvent....

Answer 1

SN2 reactions are favoured by polar aprotic solvents like DMSO and acetone and they proceed with strong nucleophile like CH3O​-,  CN-, RS-, N3-, HO-. 

Answer 2

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No matter if it is an SN1 or SN2 reaction, polar solvents are generally preferred to use. However, in substitution reactions, we focus on whether the solvent is polar protic or polar aprotic. ... The polar protic solvent can interact electrostatically with the nucleophile thereby stabilizing it.


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