Question

Apixaban suppresses the release of tf-positive microvesicles and restrains cancer cell proliferation through directly inhibiting tf-fviia activity

Answer 1

Answer:

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Answer 2

Explanation:

'Apixaban' suppresses the release of 'TF-Positive Micro-vesicles' and restrains 'Cancer Cell proliferation' through directly inhibiting 'TF-fVIIa activity.'

Apixaban is an anticoagulant which is used to treat and prevent blood clots, thus reducing the risk of 'stroke' in patients with atrial fibrillation.

This Direct Oral Anticoagulant Apixaban inhibits the release and proliferation of TF+MV from the two lines of cells, 'MDA-MB-231' and 'AsPC-1'. It was observed that incubating 'purified fVIIa' with Apixaban causes complete inhibition of the proteolytic activity of the fVIIa.