Approach to a child with immunodeficiency
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Complement defect must always be considered in patients with early onset SLE, SLE with unusual infections and family history of SLE. Simple laboratory investigation such as complete blood count and serum immunoglobulin level gives important diagnostic clue.
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Clinical manifestations include recurrent bacterial infections that begin early in life. These include pneumonia, sinusitis, osteomyelitis, skin and soft tissue infections, and deep-seated abscesses. Patients with WHIM syndrome can handle viral infections except HPV and Epstein-Barr virus (EBV).
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