Question

Arrange following sequence
1. Hydrolysis
2. Cleavage
3. Formation of fratose-1:6 bisphosha
4. Second substrate -level phosphaterylato

Answer 1

We have already used the COG approach to demonstrate the complementarity of the phyletic patterns of the three forms of phosphoglycerate mutase (see 2.2.6). Figure 7.1 shows the COGs that are known or predicted to include glycolytic enzymes and shows their phyletic patterns. This superposition of COGs and metabolic pathways provides a convenient framework for a detailed analysis of the phylogenetic distribution of each of the glycolytic enzymes and the general principles of evolution of carbohydrate metabolism. This figure shows, for example, that R. prowazekii, an obligate intracellular parasite and a relative of the mitochondria [30], does not encode a single glycolytic enzyme. In contrast, all other organisms with completely sequenced genomes encode enzymes of the lower (tri-carbon) part of the pathway. This supports the notion that glycolysis is the central pathway of carbohydrate metabolism and makes comparative analysis of variants of this pathway all the more interesting.