Question

Article on iv labetalol as premedication for attenuating hemodynamic reaponse to laryngoscope

Answer 1

Attenuation of hemodynamic response to

laryngoscopy and endotracheal intubation with two

different doses of labetalol in hypertensive patients

Rajender Kumar *, Ritika Gandhi, Indira Mallick, Rachna Wadhwa,

Nandita Adlakha, Meenaxi Bose

Department of Anaesthesia & Intensive Care, Dr. Baba Saheb Ambedkar Medical College & Hospital, Sector-6, Rohini, New Delhi

110085, India

Received 2 October 2015; accepted 24 April 2016

KEYWORDS

Labetalol;

Hemodynamic response;

Laryngoscopy and tracheal

intubation

Abstract Purpose: The present study compared the efficacy of two different doses of labetalol, for

attenuation of hemodynamic response to laryngoscopy and intubation in hypertensive patients.

Patients and methods: 75 hypertensive patients, aged 18–60 years undergoing elective surgical procedures,

require general anesthesia and orotracheal intubation. Patients were allocated to any of the

three groups (25 each), Group C (control) 5 ml 0.9% saline. Group L1 (labetalol) 0.15 mg/kg

diluted with 0.9% saline to 5 ml. Group L2 (labetalol) 0.3 mg/kg diluted with 0.9% saline to

5 ml. In the control group 5 ml of 0.9% saline was given i.v. 5 min prior to intubation. In the L1

group 0.15 mg/kg of labetalol was given i.v. 5 min prior to intubation. In the L2 group 0.3 mg/

kg of labetalol was given i.v. 5 min prior to intubation. All the patients were subjected to the same

standard anesthetic technique. Heart rate (HR), systolic blood pressure (SBP) and diastolic blood

pressure (DBP) were recorded prior to induction, at time of intubation and 1, 3, 5, and 10 min after

intubation. Mean arterial pressure (MAP) and rate pressure product (RPP) were calculated.

Results: Compared to placebo both the doses of labetalol (0.15 mg/kg) and (0.3 mg/kg) significantly

attenuated the rise in heart rate, systolic blood pressure, and RPP during laryngoscopy

and intubation. However, the difference was not statistically significant between both doses of labetalol

at intubation, 1 min, 3 min and 10 min post-intubation.

Conclusion: Both doses of labetalol (0.15 mg/kg and 0.3 mg/kg) attenuate hemodynamic response

to laryngoscopy and intubation in dose dependent manner.