ASBT transport requiredment contains
Answers
Answer:
ASBT (apical sodium-dependent bile acid transporter)
Aliases: IBAT, ISBT, NTCP2, PBAM
Gene name: Solute carrier family 10 member 2 (SLC10A2)
Summary
ASBT is Na-dependent uptake transporter of bile acids and conjugates. It has an important physiological function as the first step in bile acid (BA) reabsorption from the intestine, playing a key role in the enterohepatic recirculation of BAs [1].
Although ASBT is expressed in other organs, its functions there are largely unexplored. Genetic polymorphisms have been identified, and BA malabsorption is associated with non-functioning ASBT in humans. Diseases of the gastrointestinal tract (GIT) are notoriously difficult to characterize and accurately diagnose, but it appears likely that functionally relevant genetic polymorphisms of ASBT are at least partly implicated in a number of GIT disease states.
Although there are no known drug substrates of ASBT, there are recent reports of potent in vitro inhibition by important drug classes such as calcium channel blockers and statins, which may have previously unrecognized clinical relevance. ASBT has been variously identified as a potential pharmacological target and a mediator for directed drug delivery. While many of these applications still appear to be in the research stages, several ASBT inhibitors have progressed into clinical trials and one of them was recently launched in Japan for the treatment of chronic idiopathic constipation. As there are no clear associations of ASBT with DDI or food-drug interactions, there are no recommendations for ASBT transporter investigation in either the FDA or EMA guidelines.