Question

Assertion: A change in the nitrogen base at the third position of the codon causes change in the expression of the codon.
Reason: A codon is mostly read by all the three nitrogen bases.

Answer 1

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According to Wobble hypothesis, only the first two positions of triplet codon on mRNA have a precise pairing with the bases of the tRNA anticodon. The pairing of the thrid position bases of the codon may be ambiguous and varies according to the base at this position. For example, G may pair with U. The conventional pairing A=U,G=C is known as Watson-Crick pairing and second abnnormal pairing is called Wobble pairing.

Answer 2

Answer:

According to Wobble hypothesis, only the first two positions of triplet codon on mRNA have a precise pairing with the bases of the tRNA anticodon. The pairing of the thrid position bases of the codon may be ambiguous and varies according to the base at this position. For example, G may pair with U. The conventional pairing A=U,G=C is known as Watson-Crick pairing and second abnnormal pairing is called Wobble pairing.