at temperature beyond optimum (a) can affect the shape of an enzyme (b) lower the energy of activation (c)makes less effective to disease (d) both a and c
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At high temperatures the shape of the enzyme is altered so that it is no longer complementary to its specific substrate. This effect can be permanent and irreversible and is called denaturation .
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A is the answer
This optimal temperature is usually around human body temperature (37.5 oC) for the enzymes in human cells. Above this temperature the enzyme structure begins to break down (denature) since at higher temperatures intra- and intermolecular bonds are broken as the enzyme molecules gain even more kinetic energy.
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