Question

Autism spectrum disorders (ASDs) are childhood neurodevelopmental disorders with complex genetic origin. Previous studies focusing on candidate genes or genomic regions have identified several copy number variations (CNVs) that are associated with an increased risk of ASDs. CNVs within or surrounding genes involved in the ubiquitin pathways, including UBE3A, PARK2, RFWD2, and FBXO40, were affected by CNVs not observed in controls.

Hypothesize the role that genes involved in ubiquitin pathways play in ASDs.

Would you expect both alleles to show the same CNVs? Explain your answer.

Which scenario would most likely result in ASDs: a) CNVs that disrupt a single gene or b) CNVs disrupt multiple genes? Explain your answer.

Answer 1

Answer:

Explanation:

1)the increase of CNVs caused them to affect BE3A PARK2 RFWD and FBXO40 thisincreased autism ASD

2)

3) b disrupting more genes increases the risk of autism as it is more likely