B-cell epitopes in native proteins generally are hydrophilic amino acids on the protein surface that are topographically accessible to membrane-bound or free antibody.
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Epitopes are regions on antigens where it recognises the antibody as a foreign particle. The property of epitope in B-cell is different from the property of T-cell. B-cells recognise the soluble antigens that bind the membrane bound antibodies. And the epitopes have high accessibility on the topographical surface.
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