Balgair 2006 scenario of hemoglobin variants in central east coast of india
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Haemoglobinopathies are the most common monogenic
inherited disorders of erythrocytes. Carriers of haemo-
globinopathies are partially protected against morbidity
and mortality of falciparum malaria, resulting in their
higher prevalence in tropical countries. Estimates in
India show 3–17% prevalence of b-thalassaemia, but
its magnitude in the Central-East coast of India, especially
in Orissa is not known. One thousand fifteen cohort
cases of anaemia were analysed, referred from differ-
ent peripheral hospitals and medical colleges and hos-
pitals in the Central-East coast of India during 1994 to
2003. Background data of each individual were re-
corded like age, sex, caste, place of origin, consanguinity,
etc. Standardized laboratory procedures and techniques
were followed. Most common haemoglobinopathies
observed out of 1015 cases were: sickle cell trait
(29.8%), sickle cell disease (7.5%), sickle cell-b-tha-
lassaemia (1.7%), b-thalassaemia trait (18.2%), b-tha-
lassaemia major (5.3%), thalassaemia intermedia
(0.9%), Hb E trait (0.9%), Hb E disease (0.3%), Hb E-
b-thalassaemia (0.7%), Hb D trait (0.2%) and SD dis-
ease (0.2%). Sickle cell disorders with high level of
foetal Hb were common in general castes (0.3–20.7%),
scheduled castes (0–8.9%) and scheduled tribals (0–
5.5%). Transfusion-dependent b-thalassaemia syndrome
was prevalent among Brahmins, Karans, Khandayats,
Telis, etc. Most of the cases belong to Anugul district,
followed by Khurda, Nayagarh, Kandhamal, Cuttack,
Jajpur, Dhenkanal, Ganjam, Keonjhar, Mayurbhanj,
etc. The heterogeneous population harbours almost all
major haemoglobinopathies in general castes, scheduled
castes and tribes, belonging to coastal and southwestern
regions of Orissa. This study provides a comprehen-
sive database on the pattern of spectrum of haemoglo-
binopathies in the Central-East coast of India.
inherited disorders of erythrocytes. Carriers of haemo-
globinopathies are partially protected against morbidity
and mortality of falciparum malaria, resulting in their
higher prevalence in tropical countries. Estimates in
India show 3–17% prevalence of b-thalassaemia, but
its magnitude in the Central-East coast of India, especially
in Orissa is not known. One thousand fifteen cohort
cases of anaemia were analysed, referred from differ-
ent peripheral hospitals and medical colleges and hos-
pitals in the Central-East coast of India during 1994 to
2003. Background data of each individual were re-
corded like age, sex, caste, place of origin, consanguinity,
etc. Standardized laboratory procedures and techniques
were followed. Most common haemoglobinopathies
observed out of 1015 cases were: sickle cell trait
(29.8%), sickle cell disease (7.5%), sickle cell-b-tha-
lassaemia (1.7%), b-thalassaemia trait (18.2%), b-tha-
lassaemia major (5.3%), thalassaemia intermedia
(0.9%), Hb E trait (0.9%), Hb E disease (0.3%), Hb E-
b-thalassaemia (0.7%), Hb D trait (0.2%) and SD dis-
ease (0.2%). Sickle cell disorders with high level of
foetal Hb were common in general castes (0.3–20.7%),
scheduled castes (0–8.9%) and scheduled tribals (0–
5.5%). Transfusion-dependent b-thalassaemia syndrome
was prevalent among Brahmins, Karans, Khandayats,
Telis, etc. Most of the cases belong to Anugul district,
followed by Khurda, Nayagarh, Kandhamal, Cuttack,
Jajpur, Dhenkanal, Ganjam, Keonjhar, Mayurbhanj,
etc. The heterogeneous population harbours almost all
major haemoglobinopathies in general castes, scheduled
castes and tribes, belonging to coastal and southwestern
regions of Orissa. This study provides a comprehen-
sive database on the pattern of spectrum of haemoglo-
binopathies in the Central-East coast of India.
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