Basal lamina is made up of ............???
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The basal lamina consists of a mixture of collagens, laminin (glycoprotein), perlecan (heparan sulphate glycoprotein), entactin (glycoprotein). These proteins can bind to each other to make a highly crosslinked extracellular matrix as shown in this diagram.
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Basal laminas are composed of a lattice-type network of type IV collagen intertwined with a network of laminin. This structure is stabilized by the binding of entactin/nidogen to the collagen and laminin. The heparan sulfate proteoglycan perlecan and other molecules are associated with the type IV collagen-laminin backbone.
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