Question

bayils hilman reaction

Answer 1

The Baylis–Hillman reaction is a carbon-carbon bond forming reaction between the α-position of an activated alkene and a carbon electrophile such as an aldehyde. Employing a nucleophilic catalyst, such as a tertiary amine and phosphine, this reaction provides a densely functionalized product (e.g. functionalized allyl alcohol in the case of aldehyde as the electrophile).[1][2] It is named for Anthony B. Baylis and Melville E. D. Hillman, two of the chemists who developed this reaction while working at Celanese. This reaction is also known as the Morita–Baylis–Hillman reaction or MBH reaction, as Morita had published earlier work[3] on it.

Baylis-Hillman reactionNamed afterAnthony B. Baylis 
Melville E. D. HillmanReaction typeCoupling reactionIdentifiersOrganic Chemistry Portalbaylis-hillman-reactionRSC ontology IDRXNO:0000076

DABCO is one of the most frequently used tertiary amine catalysts for this reaction. In addition, nucleophilic amines such as DMAPand DBU as well as phosphines have been found to successfully catalyze this reaction.

MBH reaction has several advantages as a useful synthetic method: 1) It is an atom-economic coupling of easily prepared starting materials. 2) Reaction of a pro-chiral electrophile generates a chiral center, therefore an asymmetric synthesis is possible. 3) Reaction products usually contain multiple functionalities in a proximity so that a variety of further transformations are possible. 4) It can employ a nucleophilic organo-catalytic system without the use of heavy metal under mild conditions.

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